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SMTP is used to send mail. Sendmail, Qmail, Postfix, Exim etc all are used on Linux as mail server. Mail server uses the TCP port 25. Following two iptable rule allows incoming SMTP request on port 25 for server IP address (open port 25):
iptables -A INPUT -p tcp -s 0/0 --sport 1024:65535 -d --dport 25 -m state --state NEW,ESTABLISHED -j ACCEPT

iptables -A OUTPUT -p tcp -s --sport 25 -d 0/0 --dport 1024:65535 -m state --state ESTABLISHED -j ACCEPT

In order to block port 25 simply use target REJECT instead of ACCEPT in above rules.

And following two iptables rules allows outgoing SMTP server request for server IP address
iptables -A OUTPUT -p tcp -s --sport 1024:65535 -d 0/0 --dport 25 -m state --state NEW,ESTABLISHED -j ACCEPT

iptables -A INPUT -p tcp -s 0/0 --sport 25 -d --dport 1024:65535 -m state --state ESTABLISHED -j ACCEPT

Linux Iptables block all network traffic

You would like to block all network traffic using iptables firewall under Debian GNU/Linux. This will block all incoming and outgoing traffic including Internet aka ADSL/ppp0 and it is highly recommend. The logic is block everything and allow only required traffic. This can be done with four simple commands:

# iptable -F
# iptables -P INPUT DROP
# iptables -P OUTPUT DROP
# iptables -P FORWARD DROP

Please do not enter above command over remote ssh login session.