You can easily backup large files using Linux backup software combination - tar, split and md5sum program. From the article:
I have a directory containing some files for a virtual computer. The files that hold the data for the virtual computer's hard discs are not only big, they are also "sparse" files, which means that they use only enough disc space for the data that was actually written to the file. For example, the virtual computer may have a 30GB drive of which 2GB has been used. Even though it uses only 2GB on my hard disc, a program that reads the file may see it as a 30GB file. This type of file can be tricky to back up because, when you copy it, you can end up with a 30GB file, or it might simply fail to copy, depending on the type of file system used on the backup storage.