VirtualBox is a virtual emulator like VMWare workstation. It has many of the features VMWare has, as well as some of its own.
I really like new Opensource VirtualBox from Sun. It is light on resources. Here is a quick tip – you can convert a VMware virtual machine to a VirtualBox machine using qemu-img utility. Sysadmin because even developers need heroes!!!
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Wine (Wine Is Not an Emulator) is an open source implementation of the Windows API which aims to allow Linux / Unix-like systems to execute programs written for Microsoft Windows. It does not require Microsoft Windows, but can use native Windows DLLs if they are available. It provides both a development toolkit for porting Windows source code to Unix as well as a program loader, allowing many unmodified Windows programs to run on x86-based Unixes. You can easily run MS-Office, Photoshop, IE browser and selected games under Wine software.
Finally, after 12 years of development, version 1.0 was released today i.e. June 17, 2008 under GPL License.
=> Visit wine project website to grab version 1.0.